Effect of Diisopropyl Phosphorofluoridate in Some Aspects of Carbohydrate Metabolism

Authors

  • A. K. Chatterjee Defence Research & Development Establishment, Gwalior
  • U. Kaveeshwar Defence Research & Development Establishment, Gwalior

DOI:

https://doi.org/10.14429/dsj.41.4420

Keywords:

Glycogenolysis, Hyperglycemia, Glycolytic rate, LDH activity

Abstract

An acute dose of DFP equivalent to 50 per cent of the LD50 cause glycogenolysis and hyperglycemia in male albino rats. The hyperglycemic effect can atleast be partially suppressed by the administration of insulin. Under sub-acute dose equivalent to 5 per cent of the LD50, there is glycogenolysis but no change is blood glucose. The action of DFP on carbohydrate metabolism seems to be mediated through adrenal gland. DFP also increases the glycolytic rate, suppresses the LDH activity and is hepatotoxic.

Author Biographies

A. K. Chatterjee, Defence Research & Development Establishment, Gwalior

Defence Research & Development Establishment, Gwalior

U. Kaveeshwar, Defence Research & Development Establishment, Gwalior

Defence Research and Development Establishment, Gwalior

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Published

2013-01-01

How to Cite

Chatterjee, A. K., & Kaveeshwar, U. (2013). Effect of Diisopropyl Phosphorofluoridate in Some Aspects of Carbohydrate Metabolism. Defence Science Journal, 41(2), 143–147. https://doi.org/10.14429/dsj.41.4420

Issue

Vol. 41 No. 2

Section

Biomedical Sciences

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