Comparative Evaluation of High Protein against Normal Protein Diet in Combination with Carbamates against Organophosphorus Intoxication in Rats

  • A. K. Chatterjee Defence Research & Development Establishment, Gwalior
  • Nirmala Sikder Defence Research & Development Establishment, Gwalior
  • A. K. Sikder Defence Research & Development Establishment, Gwalior
Keywords: Diisopropyl phosphorofluoridate, Methyl isopropyl phosphonofluoridate, Nerve gas toxicity

Abstract

The relative efficacy of an isocaloric high (HPD) containing 59 per cent protein, in comparison to a conventional diet containing 21 per cent protein as applied in the alleviation of toxicity of diisopropyl phosphorofluoridate (DFP) and methyl isopropyl phosphonofluoridate (sarin), has been reported. In combination with well-known prophylactics like carbamates and cholinolytics like atropine against nerve gas toxicity, HPD appears to be superior to the conventional diet as studied by survival time measurements. Apart from carbamates, atropine and mecamylamine, HPD may be treated as an additional prophylactic agent to guard against the toxicity of DFP and sarin, which are being used as war chemicals.

Author Biographies

A. K. Chatterjee, Defence Research & Development Establishment, Gwalior
Defence Research & Development Establishment, Gwalior
Nirmala Sikder, Defence Research & Development Establishment, Gwalior
Defence Research & Development Establishment, Gwalior.
A. K. Sikder, Defence Research & Development Establishment, Gwalior
Defence Research & Development Establishment, Gwalior.
Published
2013-01-01
How to Cite
Chatterjee, A., Sikder, N., & Sikder, A. (2013). Comparative Evaluation of High Protein against Normal Protein Diet in Combination with Carbamates against Organophosphorus Intoxication in Rats. Defence Science Journal, 44(1), 11-14. https://doi.org/10.14429/dsj.44.4145
Section
Special Issue Papers