Comparative Evaluation of High Protein against Normal Protein Diet in Combination with Carbamates against Organophosphorus Intoxication in Rats

Abstract

The relative efficacy of an isocaloric high (HPD) containing 59 per cent protein, in comparison to a conventional diet containing 21 per cent protein as applied in the alleviation of toxicity of diisopropyl phosphorofluoridate (DFP) and methyl isopropyl phosphonofluoridate (sarin), has been reported. In combination with well-known prophylactics like carbamates and cholinolytics like atropine against nerve gas toxicity, HPD appears to be superior to the conventional diet as studied by survival time measurements. Apart from carbamates, atropine and mecamylamine, HPD may be treated as an additional prophylactic agent to guard against the toxicity of DFP and sarin, which are being used as war chemicals.