Comparative Evaluation of Carbamates as Prophylactic Agents against Organophosphate Intoxication Rats

Authors

  • A. K. Chatterjee Defence Research & Development Establishment, Gwalior

DOI:

https://doi.org/10.14429/dsj.42.4354

Keywords:

Carbamates, Physostigmine, Pyridostigmine, Nerve gas toxicity, DFP poisoning

Abstract

Investigates the effects of two well-known carbamates, physostigmine and pyridostigmine against organophosphorous compound and nerve gas toxicity. Physostigmine pretreatment for 30 min enhanced the survival time of rats against DFP intoxication whereas it did not have any effect with sarin poisoning. However, pyridostigmine pretreatment did not produce any significant effect on survival time either against DFP or sarin intoxication. Treatment with atropine along with carbamates further enhanced significantly the survival time against DFP poisoning.

Author Biography

A. K. Chatterjee, Defence Research & Development Establishment, Gwalior

Defence Research and Development Establishment, Gwalior

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Published

2013-01-01

How to Cite

Chatterjee, A. K. (2013). Comparative Evaluation of Carbamates as Prophylactic Agents against Organophosphate Intoxication Rats. Defence Science Journal, 42(2), 85–87. https://doi.org/10.14429/dsj.42.4354

Issue

Vol. 42 No. 2

Section

Biomedical Sciences

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