Comparative Evaluation of Carbamates as Prophylactic Agents against Organophosphate Intoxication Rats

  • A. K. Chatterjee Defence Research & Development Establishment, Gwalior
DOI: https://doi.org/10.14429/dsj.42.4354
Keywords: Carbamates, Physostigmine, Pyridostigmine, Nerve gas toxicity, DFP poisoning

Abstract

Investigates the effects of two well-known carbamates, physostigmine and pyridostigmine against organophosphorous compound and nerve gas toxicity. Physostigmine pretreatment for 30 min enhanced the survival time of rats against DFP intoxication whereas it did not have any effect with sarin poisoning. However, pyridostigmine pretreatment did not produce any significant effect on survival time either against DFP or sarin intoxication. Treatment with atropine along with carbamates further enhanced significantly the survival time against DFP poisoning.

Author Biography

A. K. Chatterjee, Defence Research & Development Establishment, Gwalior
Defence Research and Development Establishment, Gwalior
Published
2013-01-01
How to Cite
Chatterjee, A. (2013). Comparative Evaluation of Carbamates as Prophylactic Agents against Organophosphate Intoxication Rats. Defence Science Journal, 42(2), 85-87. https://doi.org/10.14429/dsj.42.4354
Issue
Vol 42 No 2
Section
Biomedical Sciences
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