Structure-biological Activity Relationship of Analogues of 2-Chlorobenzylidenemalononitrile -A Riot-control Agent

  • P. K. Gutch Defence Research & Development Establishment, Gwalior
  • Pravin Kumar Defence Research & Development Establishment, Gwalior
  • M.V.S. Suryanarayana Defence Research & Development Establishment, Gwalior
  • R. C. Malhotra Defence Research & Development Establishment, Gwalior
Keywords: Benzylidenemalonitriles, BMNs, riot-control agent, vapour pressure, RD, , hydrophobic& high-performance liquid chromatography, diethylaminoethyl mercaptans, 2-chlorobenzylidenemalononitrile, CS, sensory irritants

Abstract

The riot-control agent 2-chlorobenzylidenemalononitrile (CS) and its ortho-and parasubstituted benzylidenemalononitrile (BMN) analogues were synthesised and characterised by spectroscopic techniques (IR, NMR, and mass spectrometry) and microanalysis, and their structure-biological activity relationship studies were carried out to know the factors responsible for sensory irritation. Hydrophobicity of substituted BMNs were determined by high-performance liquid chromatography (HPLC), which is an important determinant of the irritancy. The vapour pressure of a compound is a physico-chemical property important for the assessment of its fate in the environment. The vapour pressures of BMNs were determined by static method by an isoteniscope. A systematic investigation of sensory irritation was carried out by evaluating decrease in respiratory rate (RDs,) in mice. The R.Dsi as biological parameter was correlated with physical parameters such as hydrophobicity, vapour pressure, size of molecules, and chemical reactivity of its BMNs with dimethylaminoethyl mercaptans (DEAEMs) as a simulant of protein-SH group. A biosignifkant correlation (0.75-0.80) was obtained.by correlating all the above parameters using multiple linear regression equation.
Published
2005-10-01
How to Cite
GutchP., KumarP., SuryanarayanaM., & MalhotraR. (2005). Structure-biological Activity Relationship of Analogues of 2-Chlorobenzylidenemalononitrile -A Riot-control Agent. Defence Science Journal, 55(4), 447-457. https://doi.org/10.14429/dsj.55.2006
Section
Biomedical Sciences

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