Studies in Sulphonamides Part XIII: Synthesis of Some new 1-methyl-3-aryl-2-(arylazo/N-substituted p-sulphamylbenzeneazo) propane-1, 3-diones as potential antibacterials

Authors

  • H. C. Nigam University of Delhi, Delhi
  • G. S. Saharia University of Delhi, Delhi
  • H. R. Sharma Hindu College, University of Delhi, Delhi

DOI:

https://doi.org/10.14429/dsj.32.6198

Keywords:

Sulphonamide bases

Abstract

Two 1-methyl-3-arylpropane-1,3-diones viz., 1-methyl-3(2',4'-dimethoxyphenyl)-and l-methlyl-3(3',4'-dimethoxyphenyl) propane-1,3-diones have been synthesised and coupled with diazotised simple and sulphonamide bases in presence of sodium acetate to furnish the corresponding 1-methyl-3(2',4'-3',4'-dimethoxyphenyl)-2 (arylazo/N-substituted p-sulphamylbenzeneazo)propane-1,3-diones. All these compounds were later subjected to in vitro screening against S. aureus, E. coli and p.pyocyanea when these showed considerable activity.

Author Biographies

H. C. Nigam, University of Delhi, Delhi

Department of Chemistry, University of Delhi, Delhi-110 007

G. S. Saharia, University of Delhi, Delhi

Department of Chemistry, University of Delhi, Delhi-110 007

H. R. Sharma, Hindu College, University of Delhi, Delhi

Department of Chemistry, Hindu College, University of Delhi, Delhi-110 007

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Published

2014-02-12

How to Cite

Nigam, H. C., Saharia, G. S., & Sharma, H. R. (2014). Studies in Sulphonamides Part XIII: Synthesis of Some new 1-methyl-3-aryl-2-(arylazo/N-substituted p-sulphamylbenzeneazo) propane-1, 3-diones as potential antibacterials. Defence Science Journal, 32(2), 87–94. https://doi.org/10.14429/dsj.32.6198

Issue

Vol. 32 No. 2

Section

General Papers

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