Therapeutic Efficacy of Saline and Glucose Saline against Dermally applied Sulphur Mustard Intoxication in Mice

Abstract

A single dose of saline or glucose-saline (5 mg glucose/kg) offered similar protection to mice against sulphur mustard intoxication, the extent of survival being 83 per cent as against 33 per cent without treatment. All the animals were protected when the treatment was extended by another two consecutive days in the glucose-saline treated group. Both saline and glucose-saline treatments could ameliorate the haemoconcentration as well as normalise pO/sub 2/ and % oxygen saturation. The protection conferred is attributed to the probable replenishment of fluid loss.