Comparative Study of Acetazolamide and Spironolactone on Regional Blood Distribution on Exposure to Acute Hypobaric Hypoxia

S. C. Jain; M. V. Singh; S. B. Rawal; H. M. Divekar; R. Parshad

doi:10.14429/dsj.35.6037

S. C. Jain Defence Institute of Physiology and Allied Sciences, Delhi Cantt
M. V. Singh Defence Institute of Physiology and Allied Sciences, Delhi Cantt
S. B. Rawal Defence Institute of Physiology and Allied Sciences, Delhi Cantt
H. M. Divekar Defence Institute of Physiology and Allied Sciences, Delhi Cantt
R. Parshad Defence Institute of Physiology and Allied Sciences, Delhi Cantt

DOI: https://doi.org/10.14429/dsj.35.6037

Keywords: Oral treatment, Radio iodinated serum albumin

Abstract

Regional blood distribution was studied in rats, which were divided into four groups viz., (i) control, (ii) exposed to acute hypobaric hypoxia, (iii) exposed to acute hypobaric hypoxia after oral treatment with 25mg acetazolamide, and (iv) exposed to acute hypobaric hypoxia after oral treatment with 6mg spironolactone. The regional blood distribution was measured using radio-iodinated serum albumin (R131ISA). The acute hypoxic exposure results in major readjustment in the blood flow to the various organs mainly from the renal and splanchic vascular beds to the heart and brain. Treatment with acetazolamide and spironolactone results only in a slight decrease in blood contents of the heart, brain and lung as compared to thehypoxia alone exposed group.