Electron Microscopical Study on Skin Lesions Induced by Sulphur Mustard

  • R. S. Chauhan Defence Research & Development Establishment, Gwalior
  • L.V.R. Murthy Defence Research & Development Establishment, Gwalior
Keywords: Collagen bandles, Collagenous extracellular matrix (ECM), Dorso caudal, Mustard gas

Abstract

Mustard gas or sulphur mustard (SM) was applied on the dorso-caudal surface of mice to examine the effect of SM on the collagenous extracellular matrix (ECM) of the mouse skin. The animals were sacrificed on first, third and sixth days to study structural changes in the ECM of the mouse skin. Disruption of ordered arrangement of collagen bundles was observed on different days. The bundles of collagen fibres were found opened up into small fragments on the third day post-exposure. Infiltration of polymorphonuclear cells and damage to the wall surrounding the blood vessels were observed. Reformation of ordered layers of collagen bundles and the narrowing of voids were taken as indicators of recovery which became perceptible on the sixth day after exposure.

Author Biographies

R. S. Chauhan, Defence Research & Development Establishment, Gwalior
Defence Research & Development Establishment, Gwalior.
L.V.R. Murthy, Defence Research & Development Establishment, Gwalior
Defence Research & Development Establishment, Gwalior.
Published
2013-01-01
How to Cite
ChauhanR., & MurthyL. (2013). Electron Microscopical Study on Skin Lesions Induced by Sulphur Mustard. Defence Science Journal, 46(1), 15-19. https://doi.org/10.14429/dsj.46.4039
Section
Biomedical Sciences

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