Protection against Radiation Induced Performance Decrement in Mice

  • S. K. Mukherjee Institute of Nuclear Medicine & Allied Sciences, Delhi
  • Kanchan Pant Institute of Nuclear Medicine & Allied Sciences, Delhi
  • H.C. Goel Institute of Nuclear Medicine & Allied Sciences, Delhi
  • Viney Jain Institute of Nuclear Medicine & Allied Sciences, Delhi
Keywords: Behavioural abnormalities, Diltiazem, Gamma radiation, Radiation exposure, Radioprotectors, Low level ionizing radiations

Abstract

Recognising that there is lack of information on the effects of low-level ionizing radiations and the modifying role of radioprotectors, an attempt has been made in this study to explore the relationship between impairment of spatial learning and low level of radiation exposure. A radial arm maze was utilised to evaluate radiation-induced behavioural alterations and performance decrement in mice. Immediately after whole body exposure to gamma radiation (absorbed dose, I Gy) significant perturbations in the learned behaviour of the animals were observed. The regular control movement became irregular and the food consumption time was reduced appreciably (40 %). Recovery took place in four days. If diltiazem (7 mg/kg b.w.), a Ca/sup 2+/ channel blocker and a radioprotector, was administered i.p. 20-30 min prior to irradiation, radiation-induced behavioural abnormalities were reduced. Mechanisms underlying protection by diltiazem against radiation-induced performance decrement observed in the present study need to be investigated.

Author Biographies

S. K. Mukherjee, Institute of Nuclear Medicine & Allied Sciences, Delhi
Institute  of Nuclear Medicine & Allied Sciences. Delhi.
Kanchan Pant, Institute of Nuclear Medicine & Allied Sciences, Delhi
Institute  of Nuclear Medicine & Allied Sciences. Delhi.
H.C. Goel, Institute of Nuclear Medicine & Allied Sciences, Delhi
Institute  of Nuclear Medicine & Allied Sciences. Delhi.
Viney Jain, Institute of Nuclear Medicine & Allied Sciences, Delhi
Institute  of Nuclear Medicine & Allied Sciences. Delhi.
Published
2013-01-01
How to Cite
MukherjeeS., PantK., GoelH., & JainV. (2013). Protection against Radiation Induced Performance Decrement in Mice. Defence Science Journal, 47(2), 167-171. https://doi.org/10.14429/dsj.47.3990
Section
Biomedical Sciences