Preparation of Oxime HI-6 (Dichloride and Dimethanesulphonate)ŒAntidote against Nerve Agents

  • Kamil Kuca Center of Advanced Studies, Hradec Kralove
  • Petr Stodulka Center of Advanced Studies, Hradec Kralove
  • Martina Hrabinova Center of Advanced Studies, Hradec Kralove
  • Petra Hanusova Vakos XT, Prague
  • Daniel Jun Department of Toxicology, Hradec Kralove
  • Bohumil Dolezal Vakos XT, Prague
DOI: https://doi.org/10.14429/dsj.58.1660
Keywords: HI-6, acetylcholinesterase, nerve agent, quaternary salts, oxime, reactivator, antidote, organophosphate

Abstract

Because of the threat of misuse of nerve agents as terroristic weapons by the terrorists, animmediate need is felt for the preparation of antidotes on large-scale basis.  HI-6 (dichloride anddimethanesulphonate) salt are the most promising acetylcholinesterase reactivators used ascausal antidotes in nerve agents intoxication. In this study, rapid and large-scale preparationof oxime HI-6, the most promising reactivator has been described.
Published
2008-05-01
How to Cite
Kuca, K., Stodulka, P., Hrabinova, M., Hanusova, P., Jun, D., & Dolezal, B. (2008). Preparation of Oxime HI-6 (Dichloride and Dimethanesulphonate)ŒAntidote against Nerve Agents. Defence Science Journal, 58(3), 399-404. https://doi.org/10.14429/dsj.58.1660
Issue
Vol 58 No 3
Section
Short Communication
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