Preparation of Oxime HI-6 (Dichloride and Dimethanesulphonate)ŒAntidote against Nerve Agents

Authors

  • Kamil Kuca Center of Advanced Studies, Hradec Kralove
  • Petr Stodulka Center of Advanced Studies, Hradec Kralove
  • Martina Hrabinova Center of Advanced Studies, Hradec Kralove
  • Petra Hanusova Vakos XT, Prague
  • Daniel Jun Department of Toxicology, Hradec Kralove
  • Bohumil Dolezal Vakos XT, Prague

DOI:

https://doi.org/10.14429/dsj.58.1660

Keywords:

HI-6, acetylcholinesterase, nerve agent, quaternary salts, oxime, reactivator, antidote, organophosphate

Abstract

Because of the threat of misuse of nerve agents as terroristic weapons by the terrorists, animmediate need is felt for the preparation of antidotes on large-scale basis.  HI-6 (dichloride anddimethanesulphonate) salt are the most promising acetylcholinesterase reactivators used ascausal antidotes in nerve agents intoxication. In this study, rapid and large-scale preparationof oxime HI-6, the most promising reactivator has been described.

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Published

2008-05-01

How to Cite

Kuca, K., Stodulka, P., Hrabinova, M., Hanusova, P., Jun, D., & Dolezal, B. (2008). Preparation of Oxime HI-6 (Dichloride and Dimethanesulphonate)ŒAntidote against Nerve Agents. Defence Science Journal, 58(3), 399–404. https://doi.org/10.14429/dsj.58.1660

Issue

Vol. 58 No. 3

Section

Short Communication

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