Influence of Altitude on Pulmonary Function A Comparative Study on Indian and Kyrgyz Healthy Males

  • Priya Gaur DRDO-Defence Institute of Physiology and Allied Sciences, Delhi - 110 054, India
  • Supriya Saini DRDO-Defence Institute of Physiology and Allied Sciences, Delhi - 110 054, India
  • Koushik Ray DRDO-Defence Institute of Physiology and Allied Sciences, Delhi - 110 054, India
  • Almazbek Akunov Kyrgyz Indian Mountain Biomedical Research Centre, Bishkek - 720 040, Kyrgyz Republic
  • Abdirashit Maripov Kyrgyz Indian Mountain Biomedical Research Centre, Bishkek - 720 040, Kyrgyz Republic
  • Sanjeev Kumar Sharma DRDO-Defence Institute of Physiology and Allied Sciences, Delhi - 110 054, India
  • Akpay Sarybaev Kyrgyz Indian Mountain Biomedical Research Centre, Bishkek - 720 040, Kyrgyz Republic
  • Bhuvnesh Kumar DRDO-Defence Institute of Physiology and Allied Sciences, Delhi - 110 054, India
  • Praveen Vats DRDO-Defence Institute of Physiology and Allied Sciences, Delhi - 110 054, India
Keywords: Maximal voluntary ventilation, High altitude hypoxia, Ethnicity, Spirometry, Forced vital capacity

Abstract

Variation in lung function at high altitude (HA) impacts the working capacity of individuals and may predispose body towards hypoxia induced illness. So, we investigated the changes in pulmonary function of healthy human male volunteers belonging to two different ethnicities i.e. Indian and Kyrgyz. Twenty, age and BMI matched, volunteers (Indian=10 and Kyrgyz=10) were recruited for the study. Measurement for pulmonary functions (FVC, FEV1, FEV1/FVC ratio, PEF, FEF 25-75%, MEF 25%, MEF 50%, MEF 75%, MVV) were performed on each individual at basal (800 m) and high altitude (4,111 m) on day 3,7,14 and 21. Results indicate that Kyrgyz has comparatively higher FVC, FEV1, PEF and MVV values and lower FEV1/FVC ratio upon altitude induction than those of Indian counterparts. Mid expiratory flow FEF25-75% was significantly increased in Kyrgyz upon altitude induction indicate more proficient lung emptying while only moderate increase at day 7 in Indian. MEF25% was significantly increased in Kyrgyz, while no change is observed in Indians at high altitude which indicates that 75% of lung emptying through small airways is better in Kyrgyz. MEF 50% and MEF 75% increased with altitude in both groups. For MVV, the maximum increase was ~17% in Indian at HA14 (p<0.01) and in Kyrgyz ~33% (p<0.001) at HA14 as compared to basal. Difference in lung function response observed, indicates that Kyrgyz has better pulmonary dynamics during altitude exposure as compared to Indian counterparts. The varied result observed may be due to different ethnic origin of the groups.

Author Biographies

Priya Gaur, DRDO-Defence Institute of Physiology and Allied Sciences, Delhi - 110 054, India

Ms Priya Gaur received her BTech (Biotechnology) from JIIT, Noida and M.Tech from USBT, GGSIPU, Delhi. She is currently working as a Senior Research Fellow in DRDO (Defence Institute of Physiology and Allied Sciences), Delhi. Her area of research includes understanding high altitude acclimatisation pattern in two different ethnic human population groups at 14,000 ft.

Supriya Saini, DRDO-Defence Institute of Physiology and Allied Sciences, Delhi - 110 054, India

Dr Supriya Saini received her PhD (Life Sciences) from Defence Institute of Physiology and Allied Sciences (DIPAS), DRDO, Delhi. Her area of research includes understanding high altitude acclimatisation pattern in two different ethnic human population groups at 10,000 ft.

Koushik Ray, DRDO-Defence Institute of Physiology and Allied Sciences, Delhi - 110 054, India

Dr Koushik Ray received his PhD (Physiology) from University of Calcutta, West Bengal. Currently working as Scientist ‘E’, Neurophysiology Division, DRDO (Defence Institute of Physiology and Allied Sciences), Delhi. He has 28 publication to his credit and edited one book

Almazbek Akunov, Kyrgyz Indian Mountain Biomedical Research Centre, Bishkek - 720 040, Kyrgyz Republic

Dr Almazbek Akunov received his is MD (Cardiology) from Kyrgyz Russian Slavic University (Kyrgyzstan). He obtained his PhD from National Center of Cardiology and Internal Medicine, Bishkek. Currently he is working as a senior researcher in Kyrgyz Indian Mountain Biomedical Research Centre, Bishkek, Kyrgyzstan.

Abdirashit Maripov, Kyrgyz Indian Mountain Biomedical Research Centre, Bishkek - 720 040, Kyrgyz Republic

Dr Abdirashit Maripov received his MD (Cardiology) from Kyrgyz State Medical Institute. He obtained his PhD from National Center of Cardiology and Internal Medicine, Bishkek. Currently he is working as a leading researcher in Kyrgyz Indian Mountain Biomedical Research Centre, Bishkek, Kyrgyzstan.

Sanjeev Kumar Sharma, DRDO-Defence Institute of Physiology and Allied Sciences, Delhi - 110 054, India

Dr Sanjeev Kumar Sharma Scientist ‘G’, DIPAS (Defence Institute of Physiology and Allied Sciences) received his PhD (Zoology) in 1986 from Punjab Agricultural University Ludhiana and joined DRDO in 1990. Currently he is heading the Biomedical Instrumentation and Endocrinology and Metabolism Division of DIPAS. He has two monograph, 32 publication, one book chapter and 3 patent to his credit. One of the technologies has been inducted in Indian Army and is under use.

Akpay Sarybaev, Kyrgyz Indian Mountain Biomedical Research Centre, Bishkek - 720 040, Kyrgyz Republic

Prof. Akpay Sarybaev received his MD (Cardiology) from Kyrgyz State Medical Institute in Sleep Medicine from Institute of Tuberculosis and Lung Diseases, Warsaw, Poland. He obtained his PhD from National Center of Cardiology and Internal Medicine, Bishkek. Currently working as Director, National Centre for Cardiology and Internal Medicine and Kyrgyz Indian Mountain Biomedical Research Centre, Bishkek, Kyrgyzstan

Bhuvnesh Kumar, DRDO-Defence Institute of Physiology and Allied Sciences, Delhi - 110 054, India

Dr Bhuvnesh Kumar, obtained his PhD (Verterinary Medicine) from G.B. Pant University of Agriculture and Technology, Pantnagar (Uttarakhand). Presently he is Outstanding Scientist and Director, DRDO-Defence Institute of Physiology and Allied Science, Delhi. Earlier he was Project Director of Low intensity Conflicts to Counter Terrorism and Insurgency, and the Director, Project Monitoring at Directorate of General Life Sciences, DRDO HQrs, and Director DIHAR.

Praveen Vats, DRDO-Defence Institute of Physiology and Allied Sciences, Delhi - 110 054, India

Dr Praveen Vats received his PhD (Chemistry) from CCS University, Meerut. Currently working as Scientist ‘F’ at DRDO (Defence Institute of Physiology and Allied Sciences), Delhi. He has more than 30 year of research experience in food & nutrition, photochemistry and endocrinology & metabolism. Presently he is working on understanding the effect of ethnicity on high altitude acclimatisation pattern.

Published
2020-02-19
How to Cite
Gaur, P., Saini, S., Ray, K., Akunov, A., Maripov, A., Sharma, S., Sarybaev, A., Kumar, B., & Vats, P. (2020). Influence of Altitude on Pulmonary Function A Comparative Study on Indian and Kyrgyz Healthy Males. Defence Life Science Journal, 5(1), 3-9. https://doi.org/10.14429/dlsj.5.14644
Section
General Papers