Mechanical and Swelling Properties of Poly (vinyl alcohol) and Hyaluronic Acid Gels used in Biomaterial Systems - a Comparative Study

Jagadeeshwar Kodavaty; Abhijit P. Deshpande

doi:10.14429/dsj.64.7320

Jagadeeshwar Kodavaty Department of Chemical Engineering, Indian Institute of Technology Madras, Chennai
Abhijit P. Deshpande Department of Chemical Engineering, Indian Institute of Technology Madras, Chennai

DOI: https://doi.org/10.14429/dsj.64.7320

Keywords: PVA, Hyaluronic acid, Biomaterial, Rheology, Gel

Abstract

There is an increasing demand for designing controlled drug delivery systems with materials which are morebiocompatible, economical and materials which can be processed easily. Poly (vinyl alcohol) (PVA) and hyaluronicacid (HA) are promising polymers for applications in drug delivery. PVA forms gel based on the acetal bridges when cross linked with glutaraldehyde (GA). On the other hand, HA a natural polymer, forms gel with divinyl sulfone(DVS) as a crosslinker. PVA and HA blends upon crosslinking PVA with GA or HA with DVS, in the presence ofthe other polymer, form gels that are more adaptable to the drug delivery systems. In this work, the mechanicalproperties and swelling behaviour of PVAHA gels were characterized. The effect of composition on viscoelasticmoduli and degree of swelling was determined. The storage modulus (G″) of various gels made of PVA, HA andPVAHA blends were measured using rheology and compared with the values available in the literature. Swellingproperties were measured and compared among various PVA and HA gels. Collagen is added to PVA solution andthe rheological properties were measured in the gel state. Based on the values of storage modulus, gels of variouscompositions of PVA, HA and collagen might be selected as potential biomaterials for drug delivery system dependingon careful understanding the type of application.

Defence Science Journal, Vol. 64, No. 3, May 2014, pp. 222-229, DOI:http://dx.doi.org /10.14429/dsj.64.7320

Author Biographies

Jagadeeshwar Kodavaty, Department of Chemical Engineering, Indian Institute of Technology Madras, Chennai

Mr Jagadeeshwar Kodavaty did his BTechin chemical engineering from NIT Warangaland received his MTech in biotechnologyfrom JNTU, Hyderabad. He worked asAssistant professor in the department ofchemical engineering at Sri venkateswaraengineering college, suryapet and in thedepartment of biotechbology at MITS,madanapalle. He is presently pursuing hisPhD at IIT Madras in the polymer engineering and colloidalscience group, with the guidance of Dr Abhijt P. Deshpande.His present interest is on characterization of hydrogels andbiomaterials systems using rheology.

Abhijit P. Deshpande, Department of Chemical Engineering, Indian Institute of Technology Madras, Chennai

Dr Abhijit P. Deshpande joined as a faculty member in 1996at IIT Madras and is currently working asa professor in the department of chemicalengineering. His focus of research is onunderstanding the aggregation and gelationbehavior of polymeric systems and probesthese material behaviors with rheologyas a tool. He has published 33 papers innational and international journals. He isalso edited/authored books on ‘Rheologyof complex materials’ and ‘Modeling ofengineering materials’. His present research interest is onhydrogels, polymer blends and composits, piezo electric materials,sulfonated polymers and biomaterial systems.