Synthesis and Antifungal Activity of Some New Guanidines

Authors

  • Puran Chandra Joshi Kumaun University Constituent College, Almora
  • P. C. Joshi Kumaun University Constituent College, Almora

DOI:

https://doi.org/10.14429/dsj.29.6512

Keywords:

Helminthosporium oryzae, Drechlere papendor

Abstract

The synthesis of some N-subsituted -N'-aryl-N"-ethyl/benzyl guanidines (II) and (III) and their precurser thiocarbamides (I) has been carried out. All these compounds have been screened in vitro for their antifungal activity against Helminthosporium oryzae, Drechlere papendor fii and Alternaria alternata. In general, N-substituted-N'aryl-N"benzyl guanidines except N-(p-pyrolidinopropoxyphenyl)-N'-p-tolyl-N"-benzyl guanidine possess high antifungal activity against all the test fungi at concentration 2% and comparatively less at 0.2% None of these compounds exhibit fungicidal activity at lower concentrations (0.02 and 0.002%).

Author Biographies

Puran Chandra Joshi, Kumaun University Constituent College, Almora

Department of Chemistry, Kumaun University Constituent College, Almora

P. C. Joshi, Kumaun University Constituent College, Almora

Department of Chemistry, Kumaun University Constituent College, Almora

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Published

2014-02-24

How to Cite

Joshi, P. C., & Joshi, P. C. (2014). Synthesis and Antifungal Activity of Some New Guanidines. Defence Science Journal, 29(4), 159–162. https://doi.org/10.14429/dsj.29.6512

Issue

Section

General Papers