Synthesis and Antifungal Activity of Some New Guanidines
Keywords: Helminthosporium oryzae, Drechlere papendor
AbstractThe synthesis of some N-subsituted -N'-aryl-N"-ethyl/benzyl guanidines (II) and (III) and their precurser thiocarbamides (I) has been carried out. All these compounds have been screened in vitro for their antifungal activity against Helminthosporium oryzae, Drechlere papendor fii and Alternaria alternata. In general, N-substituted-N'aryl-N"benzyl guanidines except N-(p-pyrolidinopropoxyphenyl)-N'-p-tolyl-N"-benzyl guanidine possess high antifungal activity against all the test fungi at concentration 2% and comparatively less at 0.2% None of these compounds exhibit fungicidal activity at lower concentrations (0.02 and 0.002%).
How to Cite
Joshi, P., & Joshi, P. (2014). Synthesis and Antifungal Activity of Some New Guanidines. Defence Science Journal, 29(4), 159-162. https://doi.org/10.14429/dsj.29.6512
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