Blood Coagulation Changes at High Altitude

  • I. S. Chohan Cardiothoracic Centre, Military Hospital. Pune
Keywords: Blood Coagulation Changes, High Altitude Pulmonary Oedema, High Altitude Pulmonary Hypertension


The current concepts of blood coagulation changes in the pathogenesis of acute mountain sickness (AMS), high altitude pulmonary oedema (HAPO), high altitude pulmonary hypertension (HAPH) and chronic mountain sickness(CMS) which afflict the inductees and residents at high altitude have been reviewed. Hypercoagulable state which is more marked during the first few days of exposure is countered by enhanced fibrinolytic activity and accelerated cell mediated immunity. Magnesium levels are increased in normal residents at high altitudes and may be responsible for enhancing fibrinolytic activity and accelerating immune responses. Magnesium levels are significantly reduced in HAPO patients. Judicious use of furosemide in lower dosage is still the mainstay of treatment of HAPO and AMS.

Author Biography

I. S. Chohan, Cardiothoracic Centre, Military Hospital. Pune
Cardiothoracic Centre, Military Hospital. Pune-411 040
How to Cite
Chohan, I. (2014). Blood Coagulation Changes at High Altitude. Defence Science Journal, 34(4), 361-379.
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