Cardiovascular Response to High Altitude Hypoxia
Keywords:
High Altitude Hypoxia, Hypercapnia, Cardiovascular
Abstract
Normal and abnormal cardiovascular response to high altitude (HA) hypoxia were studied in 98 healthy subjects and in 15 patients with HA pulmonary oedema (HAPO) and acute mountain sickness (AMS) at an altitudeof 3,658 m. The healthy sea level (SL) residents showed marked blood volume changes during the first week with pulmonary hypotension and depression of left ventricular (LV) performance and physical work capacity (PWC). The HA natives, however, had better LV performance and PWC indicating a better adaptation to HA hypoxia. HAPO subjects showed evidence of severe pulmonary hypertension with normal left atrial pressures but the exact mechanism of this condition is still not clear. AMS subjects showed no circulatory abnormalities 'but had relative hypercapnia and severe hypoxemia suggesting that AMS may be causcd by relative hyposensitiveness of the respiratory centre to hypoxia or hypercapnia.
Published
2014-01-30
How to Cite
Manchanda, S. (2014). Cardiovascular Response to High Altitude Hypoxia. Defence Science Journal, 34(4), 345-353. https://doi.org/10.14429/dsj.34.6081
Section
Special Issue Papers
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