Immunotoxicology: Modulation of the Immune System by Xenobiotics

  • Prakash S. Nagarkatti Virginia Polytechnic and State University, Blacksburg
  • Mitzi Nagarkatti Virginia Polytechnic and State University, Blacksburg
DOI: https://doi.org/10.14429/dsj.37.5904
Keywords: Immunotoxicological screening, Immune system, Immunity

Abstract

Starting wih a definition of immunity, this review describes general mechanisms by which immune system is modulated and details several immunotoxicological screening methods to assess the immumologic and host resistance alterations following chemical exposure. Among a variety of immuno toxic compounds known, only four representative compounds namely o-chloro benzylidine malononitrile (CS), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), chloroquine, 1,3 bis (2-chloroethyl) 1-nitrosourea (BCNU) have been chosen for an elaborate discussion.

Author Biographies

Prakash S. Nagarkatti, Virginia Polytechnic and State University, Blacksburg
Virginia Polytechnic and State University, Blacksburg, Virginia-24061
Mitzi Nagarkatti, Virginia Polytechnic and State University, Blacksburg
Virginia Polytechnic and State University, Blacksburg, Virginia-24061
Published
2014-01-15
How to Cite
Nagarkatti, P., & Nagarkatti, M. (2014). Immunotoxicology: Modulation of the Immune System by Xenobiotics. Defence Science Journal, 37(2), 235-244. https://doi.org/10.14429/dsj.37.5904
Issue
Vol 37 No 2
Section
General Papers
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