Immunotoxicology: Modulation of the Immune System by Xenobiotics

Authors

  • Prakash S. Nagarkatti Virginia Polytechnic and State University, Blacksburg
  • Mitzi Nagarkatti Virginia Polytechnic and State University, Blacksburg

DOI:

https://doi.org/10.14429/dsj.37.5904

Keywords:

Immunotoxicological screening, Immune system, Immunity

Abstract

Starting wih a definition of immunity, this review describes general mechanisms by which immune system is modulated and details several immunotoxicological screening methods to assess the immumologic and host resistance alterations following chemical exposure. Among a variety of immuno toxic compounds known, only four representative compounds namely o-chloro benzylidine malononitrile (CS), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), chloroquine, 1,3 bis (2-chloroethyl) 1-nitrosourea (BCNU) have been chosen for an elaborate discussion.

Author Biographies

Prakash S. Nagarkatti, Virginia Polytechnic and State University, Blacksburg

Virginia Polytechnic and State University, Blacksburg, Virginia-24061

Mitzi Nagarkatti, Virginia Polytechnic and State University, Blacksburg

Virginia Polytechnic and State University, Blacksburg, Virginia-24061

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Published

2014-01-15

How to Cite

Nagarkatti, P. S., & Nagarkatti, M. (2014). Immunotoxicology: Modulation of the Immune System by Xenobiotics. Defence Science Journal, 37(2), 235–244. https://doi.org/10.14429/dsj.37.5904

Issue

Vol. 37 No. 2

Section

General Papers

License

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