Drug/Xenobiotic-Metabolism, Disposition and Toxicity in Malnutrition

Abstract

The role of malnutrition and diet in general on bioprocess, which govern the fate of drug/xenobiotic in the body only just beginning to be understood. Absorption, protein binding distribution, bio-transformation and renal elimination of xenobiotics/drugs are all affected by altered states of nutrition. As such, evaluation of nutritional status is highly relevant prior to prolonged drug thereby especially with drugs having narrow safety margin.