Conceptual Approaches to Alternate Methods in Toxicological Testing

Authors

  • Alan M. Goldberg The Johns Hopkins School of Hygiene and Public Health, Baltimore
  • Andrew N. Rowan Tufts School of Veterinary Medicine, Boston

DOI:

https://doi.org/10.14429/dsj.37.5896

Keywords:

Cell biology, Computer modelling, Toxicity testing

Abstract

Due to public pressure, in vivo methods of toxicity testing is being attempted to be replaced by in vitro methods, such as cell and organ culture, computer modelling and modified LD50 tests using lesser number of animals. Specifically in the case of Draize eye irritancy test using rabbits, a number of refinements have been incorporated by different workers, mainly use of a local anaesthetic which will reduce animal distress without vitiating the test results. The author recommends exploration of new avenues for testing based on the advances in cell biology.

Author Biographies

Alan M. Goldberg, The Johns Hopkins School of Hygiene and Public Health, Baltimore

The Johns Hopkins School of Hygiene and Public Health,Baltimore, MD 21205, USA

Andrew N. Rowan, Tufts School of Veterinary Medicine, Boston

Tufts School of Veterinary Medicine, Boston, MA 02111, USA

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Published

2014-01-15

How to Cite

Goldberg, A. M., & Rowan, A. N. (2014). Conceptual Approaches to Alternate Methods in Toxicological Testing. Defence Science Journal, 37(2), 99–112. https://doi.org/10.14429/dsj.37.5896

Issue

Section

General Papers