Mechanism of Cyanide Toxicity and Efficacy of its Antidotes
Keywords: Sulphur donors, Cyanohydrin formers, Methaemoglobin formers, Cyanide intoxication, Inhibited enzymes, Chemical warfare agents, Hydrogen cyanide
AbstractThis paper attempts to review the various antidotes available for countering cyanide threat in the light of the toxicity associated with it. It also critically evaluates the drawbacks and advantages of these antidotes for their therapeutic and/or prophylactic utility. The physico-chemical properties of hydrogen cyanide which make it a chemical warfare agent have also been highlighted. In an attempt to make the complex chemical and biological processes understandable, the chemical structures of the antidotes have been included and simple mechanistic pathways have been used to show the role of antidotes in activating the inhibited enzymes.
How to Cite
Raza, S., & Jaiswal, D. (2013). Mechanism of Cyanide Toxicity and Efficacy of its Antidotes. Defence Science Journal, 44(4), 331-340. https://doi.org/10.14429/dsj.44.4188
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