Effects of Gamma Radiation on the concentration of 5 Hydroxy L Tryptophan and 5 Hydroxytryptamine in presence of Radioprotector in Sprague Dawley Rats

  • S. N. Upadhyay Institute of Nuclear Medicine & Allied Sciences, Delhi
  • Ashok Sharma Institute of Nuclear Medicine & Allied Sciences, Delhi
  • K. K. Nagpal Institute of Nuclear Medicine & Allied Sciences, Delhi
  • S. K. Saini Institute of Nuclear Medicine & Allied Sciences, Delhi
DOI: https://doi.org/10.14429/dsj.47.4021
Keywords: Radiation, Gamma radiation

Abstract

The result of variation of 5-hydroxy-L-tryptophan (HT) and S-hydroxytryptamine (S-HT) in different tissues of control and gamma-irradiated Sprague Dawley rats with and without a radioprotector Beeta-amino-ethylisothiuronium bromide hydrobromide (AET) combination e.g. (HT + AET) have been studied. The retention of HT, in the tissues studied, decreased after lethal dose (10.5 Gy) but for 5-HT, no such trend was observed after incorporation of HT + AET. A slight tendency of both metabolites to come back to control level was also observed for Sprague Dawley rats. In urine, concentration of HT was less compared to 5-HT with a lethal dose (10.5 Gy). After incorporation of HT + AET the turnover rate of HT and 5-HT were found to be maximum when it was injected through intraperitoneal route.

Author Biographies

S. N. Upadhyay, Institute of Nuclear Medicine & Allied Sciences, Delhi
SN Upadhyay is working as Scient\st E at thr Institute of Nuclear Medici,le & Allied Sciences (INMAS), Delhi. The areas of his work include bipolymer-radioprotector interaction in vitro and In VIVO.
Ashok Sharma, Institute of Nuclear Medicine & Allied Sciences, Delhi
Shri Ashok Sharma is working as Technical Assistant B INMAS in the field or radioprotectors.
K. K. Nagpal, Institute of Nuclear Medicine & Allied Sciences, Delhi
Dr KK Nagpal has obtained his BVSc and AH. He is working as Scientist D/at INMAS, in the field of radioproectors.
S. K. Saini, Institute of Nuclear Medicine & Allied Sciences, Delhi
Dr SK Saini is working asv Scientist E at the Centre for Environment & Explosive Safety (CEES) Delhi, on Photochemical oxidation of Hazardous wastes.
Published
2013-01-01
How to Cite
Upadhyay, S., Sharma, A., Nagpal, K., & Saini, S. (2013). Effects of Gamma Radiation on the concentration of 5 Hydroxy L Tryptophan and 5 Hydroxytryptamine in presence of Radioprotector in Sprague Dawley Rats. Defence Science Journal, 47(3), 383-388. https://doi.org/10.14429/dsj.47.4021
Issue
Vol 47 No 3
Section
Biomedical Sciences
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