Effects of Gamma Radiation on the concentration of 5 Hydroxy L Tryptophan and 5 Hydroxytryptamine in presence of Radioprotector in Sprague Dawley Rats
Keywords: Radiation, Gamma radiation
AbstractThe result of variation of 5-hydroxy-L-tryptophan (HT) and S-hydroxytryptamine (S-HT) in different tissues of control and gamma-irradiated Sprague Dawley rats with and without a radioprotector Beeta-amino-ethylisothiuronium bromide hydrobromide (AET) combination e.g. (HT + AET) have been studied. The retention of HT, in the tissues studied, decreased after lethal dose (10.5 Gy) but for 5-HT, no such trend was observed after incorporation of HT + AET. A slight tendency of both metabolites to come back to control level was also observed for Sprague Dawley rats. In urine, concentration of HT was less compared to 5-HT with a lethal dose (10.5 Gy). After incorporation of HT + AET the turnover rate of HT and 5-HT were found to be maximum when it was injected through intraperitoneal route.
How to Cite
Upadhyay, S., Sharma, A., Nagpal, K., & Saini, S. (2013). Effects of Gamma Radiation on the concentration of 5 Hydroxy L Tryptophan and 5 Hydroxytryptamine in presence of Radioprotector in Sprague Dawley Rats. Defence Science Journal, 47(3), 383-388. https://doi.org/10.14429/dsj.47.4021
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