Protective Role of Verapamil against Organophosphorus Ester Induced Delayed Neurotoxicity (Short Communication)

  • S. K. Dighe Defence Research & Development Establishment, Gwalior
  • A. B. Nashikkar Defence Research & Development Establishment, Gwalior
  • Mr. Purnanand Defence Research & Development Establishment, Gwalior
DOI: https://doi.org/10.14429/dsj.47.3992
Keywords: Neurotoxic effects, Atropine, Mipofox

Abstract

The protective efficacy of a well-known calcium channel blocker, Verapamil, against Mipafox, a prototype of nerve gas, has been investigated. Mipafox is a potent organophosphorus ester which has both acute and delayed neurotoxic effects. The results of the present study indicate that as an adjunct to Atropine, Verapamil shows protective action in overcoming the delayed neurotoxic effects. However, it makes either little or no contribution to the recovery of the acute toxic effects of Mipafox.

Author Biographies

S. K. Dighe, Defence Research & Development Establishment, Gwalior
Dr SK Dighe obtained his PhD from Jiwaji University, Gwalior. He joined DR:DO in 1961 at the Defence Materials & Stores Research & Development Establislunent (DMSRDE), Kanpur. Currently, he is working as Sci C at the Defence Research & Development  Establishment (DRDE), Gwaliol1- The area of his research is acute and delayed toxicological studies of oranophosphorus esters
A. B. Nashikkar, Defence Research & Development Establishment, Gwalior
Mr AB Nashlkkar obtaincd his MSc in Chcmistry in 1974 from Jiwaji University. He Joined DRDE in 1975. Currently, he is working as Tcchnical Officer A and engaged lin tre toxicological studies of organophosphorus esters aqd in monitoring hcalth of scintists exposed to toxicants in tr eir day-to- day work.
Mr. Purnanand, Defence Research & Development Establishment, Gwalior
Dr Purnanand obtained his PhD in 1974 from Jiwaji University. Gwal~or. He joined DRDO at DRDE and is presently working as by Director. He was been working in the field of resollttion of optical isomers of organophosphorus compounds of biological significance a*d has specialised in the area of decontamination of toxic substances. He has published 25 research1 papers in national and international journals and has five patents to his credit.
Published
2013-01-01
How to Cite
Dighe, S., Nashikkar, A., & Purnanand, M. (2013). Protective Role of Verapamil against Organophosphorus Ester Induced Delayed Neurotoxicity (Short Communication). Defence Science Journal, 47(2), 173-176. https://doi.org/10.14429/dsj.47.3992
Issue
Vol 47 No 2
Section
Biomedical Sciences
Copyright (c) 2016 Defence Science Journal

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