A Proteins of ANL Family FACLs and FAALs, Next Anti TB Drug Targets.

Ankuri Chakraborty; Marzuqua Kalam; Sutanu Sarkar; Deotima Roy; Momsree Bhattacharjee; Devkamal Paul; Asesh Banerjee; Dr. Prabuddha Gupta

doi:10.14429/dlsj.9.19905

Ankuri Chakraborty Amity Institute of Biotechnology, Amity University Kolkata, Rajarhat Newtown, Kolkata - 700 135, West Bengal, India. https://orcid.org/0009-0001-6219-984X
Marzuqua Kalam Amity Institute of Biotechnology, Amity University Kolkata, Rajarhat Newtown, Kolkata - 700 135, West Bengal, India. https://orcid.org/0009-0003-3405-471X
Sutanu Sarkar Amity Institute of Biotechnology, Amity University Kolkata, Rajarhat Newtown, Kolkata - 700 135, West Bengal, India. https://orcid.org/0009-0009-3913-4691
Deotima Roy Amity Institute of Biotechnology, Amity University Kolkata, Rajarhat Newtown, Kolkata - 700 135, West Bengal, India. https://orcid.org/0009-0004-6779-0948
Momsree Bhattacharjee Amity Institute of Biotechnology, Amity University Kolkata, Rajarhat Newtown, Kolkata - 700 135, West Bengal, India. https://orcid.org/0009-0001-9369-6670
Devkamal Paul Amity Institute of Biotechnology, Amity University Kolkata, Rajarhat Newtown, Kolkata - 700 135, West Bengal, India. https://orcid.org/0009-0001-2123-3431
Asesh Banerjee Amity Institute of Biotechnology, Amity University Kolkata, Rajarhat Newtown, Kolkata - 700 135, West Bengal, India. https://orcid.org/0000-0001-7483-2158
Dr. Prabuddha Gupta Amity Institute of Biotechnology, Amity University Kolkata, Rajarhat Newtown, Kolkata - 700 135, West Bengal, India. https://orcid.org/0000-0003-1009-2781

DOI: https://doi.org/10.14429/dlsj.9.19905

Keywords: FACL, FAAL, Lipid metabolism, CoA binding pocket, Inhibitors, Tuberculosis

Abstract

The adenylating enzymes (AEs) of the ANL family contribute to the lipid synthesis process in Mycobacterium tuberculosis (MTB). FAALs (Fatty Acyl-AMP Ligase) and FACLs (Fatty Acyl-CoA Ligase) are members of the ANL enzyme family and are closely associated with the metabolism of mycobacterial lipids responsible for successful infections. Therefore, given their role in both biosynthesis and breakdown processes within fatty acid metabolism, these two groups of proteins might be potential drug targets. The growing abundance of structural, biochemical, and genetic information on mycobacterial FAAL and FACL enzymes could provide a solid foundation for the creation of next-generation anti-tuberculosis drugs, via rational drug designing.