Effect of Allium Sativum on the Alcohol Induced Neuropathic Pain in Wistar Rats

Shashi Dhar Mehta; Umesh Kumar; Anil Kumar Mavi; Vinod Kumar; Suhel Parvez; Suhasini Bhatnagar

doi:10.14429/dlsj.7.17774

Shashi Dhar Mehta Department of Biochemistry, Mewar University, Chittorgarh, Rajasthan- 312 901, India https://orcid.org/0000-0002-6813-5409
Umesh Kumar School of Biosciences, Institute of Management Studies, Ghaziabad University Courses Campus, NH9, Ghaziabad, Uttar Pradesh- 201 015, India https://orcid.org/0000-0002-4715-7967
Anil Kumar Mavi Department of Pulmonary Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi- 110 007, India https://orcid.org/0000-0002-0776-8528
Vinod Kumar Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi- 110 029, India https://orcid.org/0000-0002-1048-7567
Suhel Parvez Department of Medical Elementology & Toxicology, Jamia Hamdard University, New Delhi-110 062, India https://orcid.org/0000-0002-6318-6506
Suhasini Bhatnagar Department of Biochemistry, Mewar University, Chittorgarh, Rajasthan- 312 901, India https://orcid.org/0000-0003-0406-3511

DOI: https://doi.org/10.14429/dlsj.7.17774

Keywords: Neuropathic pain, Allium sativum, Induced pain, Anti-inflammatory effect, Alcoholic neuropathy

Abstract

Neuropathic pain is a severe pain condition associated with pathological changes which have deleterious effects like dysfunction of the brain. Alcohol abuse is known to be the most common reason at present for developing neuropathic pain. Alcohol-induced neuropathic pain can be assessed by ache studies such as hyperalgesia and allodynia which characterizes the response severity of induced pain. In the current research, we used the Allium Sativum (Garlic) bulb extract to study the effect on alcohol-administered rodents. The behavioral and biochemical studies have been done. It has been reported in the study, that Allium sativum has certain protective mechanisms such as analgesic and anti-inflammatory effects, free radical scavenger, and antioxidant effects which contribute to alcohol-induced neuropathic pain. Based on the results of the current investigation, it can be concluded that Allium sativum bulb extract, administered at doses of 200 and 300 mg/kg in 0.9 per cent saline, is helpful in reducing the symptoms of alcoholic neuropathy. Allium sativum may offer a protective effect in the revocation of alcoholic-induced neuropathic pain.