Computational Analysis for Regulation of Podophyllotoxin Biosynthesis Pathway in Podophyllum with Potential Substitute Species

  • Utkarsha Srivastava Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology Himachal Pradesh-173 234, India https://orcid.org/0000-0003-1009-3338
  • Hemant Sood Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology Himachal Pradesh-173 234, India http://orcid.org/0000-0003-0001-4317
Keywords: Podophyllotoxin, Secoisolariciresinol dehydrogenase, Dirigent protein oxidase, Pluviatolide synthase, Podophyllum, BLAST

Abstract

 Podophyllum species, the source of important secondary metabolite, podophyllotoxin, is over-exploited for production of anti-cancer drugs endangering this genus globally. Lack of complete knowledge on podophyllotoxin biosynthesis is a major drawback in its cultivation and identification for alternative plants. The current study on secoisolariciresinol dehydrogenase, dirigent protein oxidase and pluviatolide synthase identifies their role in regulating podophyllotoxin biosynthesis. The present computational analysis of podophyllotoxin proposes a correlating interconnected network of pathways for podophyllotoxin biosynthesis besides identifying potential substitute species for the biosynthesis of podophyllotoxin and accounting for possible reason for variation in podophyllotoxin yield from different species of this genus

Published
2022-06-17
How to Cite
Srivastava, U., & Sood, H. (2022). Computational Analysis for Regulation of Podophyllotoxin Biosynthesis Pathway in Podophyllum with Potential Substitute Species. Defence Life Science Journal, 7(2), 97-102. https://doi.org/10.14429/dlsj.7.17445
Section
Research Article