Tyrosine Supplementation A Nutraceutical Approach to Counter Heat Stress Induced Cognitive Decline

Keywords: Tyrosine, Norepinephrine, Selective attention, Sustained attention, Reaction time


Supplementation of tyrosine, non-essential amino acid, and precursor of catecholamine was found to ameliorate the heat-induced alterations in latencies of event-related potential P300 and contingent negative variation. Here we present the effect of tyrosine supplementation on heat stress (exposure to ambient temperature 45 oC and relative humidity 30 %) induced alterations in behavior (attention, mood) and levels of plasma monoamines. Ten healthy male participants received a placebo food bar or tyrosine-containing food bar
(6.5 g in 50 g) 90 min before heat stress exposure of 90 min. Plasma and urine samples were assayed for catecholamine levels, their precursor, and metabolites using high-performance liquid chromatography. A computer-based automated test battery was used to assess attention and mood by profile of mood states questionnaire. A significantly higher plasma tyrosine (p<0.001) leading to an increased norepinephrine (p<0.05) levels in the tyrosine supplemented group was observed. Selective (p<0.001) and sustained attention (p<0.02) in the tyrosine group were significantly better compared to the placebo group. Reaction time and anger scores decreased (p<0.001) with tyrosine supplementation. It may be concluded that tyrosine supplementation improves heat stress-induced decrement in attention by maintaining the synthesis and turnover of norepinephrine.

How to Cite
Kishore, K., Ray, K., Kumar, S., Anand, J., Thakur, L., Ravi, D., Suresh, A., Kolpe, R., Kizhekkedath, J., Kumar, B., & Panjwani, U. (2021). Tyrosine Supplementation A Nutraceutical Approach to Counter Heat Stress Induced Cognitive Decline. Defence Life Science Journal, 6(3), 205-213. https://doi.org/10.14429/dlsj.6.15870
Research Article