Evaluation of Antibacterial Potential of Daldinia concentrica from North Eastern Region of India

Sewali Goswami; Imtiaz Rahman; Sumit Kishor; Sanjai Kumar Dwivedi

doi:10.14429/dlsj.5.15564

Sewali Goswami DRDO-Defence Research Laboratory, Tezpur - 784 001, India https://orcid.org/0000-0003-4304-5607
Imtiaz Rahman DRDO-Defence Research Laboratory, Tezpur - 784 001, India https://orcid.org/0000-0002-5945-8986
Sumit Kishor DRDO-Defence Research Laboratory, Tezpur - 784 001, India https://orcid.org/0000-0002-9890-6606
Sanjai Kumar Dwivedi DRDO-Defence Research Laboratory, Tezpur - 784 001, India

DOI: https://doi.org/10.14429/dlsj.5.15564

Keywords: Daldinia concentrica, Antibacterial, GC-MS, Stromata

Abstract

Morphological, bio-chemical and antibacterial potential of an ascomycetous fungus, Daldinia concentrica, was evaluated. It was collected from dead, decaying log of Mimusops elengi tree and isolated by plating in potato dextrose medium. Macroscopic and microscopic features of the stromata were studied. The crude methanol extract of the stromata (30 mg/ml) exhibited significant antibacterial activity against Escherichia coli (MTCC-40), Pseudomonas aeruginosa (MTCC-7093), Klebsiella pneumoniae (MTCC-661), Enterobacter aerogenes (MTCC-111) and Gram positive bacteria Staphylococcus aureus (MTCC-7443), Bacillus subtilis (MTCC-121). Bacillus subtilis was the most sensitive organism to the methanol extract of this fungus with 41.33 mm zone of inhibition. Gas Chromatographic–Mass Spectral Analysis of stromatal methanol extract revealed the presence of 19 compounds. The present investigation indicated the potential antibacterial activity of native D. concentrica, which could be useful for pharmaceutical application.