Advances in Rapid Detection and Antimicrobial Susceptibility Tests: A Review

Priyanka Mishra; Kamla Prasad Mishra; Divya Singh; Lilly Ganju; Bhuvnesh Kumar; Shashi Bala Singh

doi:10.14429/dlsj.4.12572

Priyanka Mishra DRDO Defence Institute of Physiology and Allied Sciences
Kamla Prasad Mishra O/o Director General Life Sciences, DRDO-HQ , New Delhi
Divya Singh DRDO Defence Institute of Physiology and Allied Sciences
Lilly Ganju DRDO Defence Institute of Physiology and Allied Sciences
Bhuvnesh Kumar DRDO Defence Institute of Physiology and Allied Sciences
Shashi Bala Singh National Institute of Pharmaceutical Education and Research (NIPER) Hyderabad.

DOI: https://doi.org/10.14429/dlsj.4.12572

Keywords: Antimicrobial susceptibility testing, Antimicrobial resistance detection, Rapid detection

Abstract

The rise of antibiotic resistance is an emerging problem of the millennium. Clinical microbiology plays an important role in combating the problem by facilitating diagnostics and therapeutics thus managing infection in patients. Diagnostic failures are a major limiting factor during bacterial infection that causes inappropriate use of antibiotics, delay in start up of treatment and decrease in the survival rate during septic conditions. Thus rapid and reliable detection is highly relevant during such bacterial infections and also at the time of disease outbreak as many such pathogens can be used as biothreat agents or bioweapons affecting human health and posing risk to national security. This review highlights the importance of various methods for fast pathogen detection and antimicrobial susceptibility determination. These methods have the potential to provide very precise and rapid ways for bacterial screening and identifying the correct antibiotics to cure infection

Author Biographies

Priyanka Mishra, DRDO Defence Institute of Physiology and Allied Sciences

Ms. Priyanka Mishra, received her M.Sc. in Biotechnology from Babasaheb Bhimrao Ambedkar University, Lucknow. Presently working as a research fellow at Immunomodulation Division, DIPAS.

Kamla Prasad Mishra, O/o Director General Life Sciences, DRDO-HQ , New Delhi

Dr. K.P. Mishra received his PhD Degree in Life Sciences from APS University Rewa. He is currently working as Scientist ‘E’ at the Directorate General Life Sciences, DRDO-HQ,
New Delhi. Prior to his posting at DRDO-HQ he was at DIPAS, Delhi. His area of research is Immunophysiology, Viral Immunology and Immunomodulation. He is elected member
of the National Academy of Sciences India and the National Academy of Medical Sciences. He has published more than 65 research papers.

Divya Singh, DRDO Defence Institute of Physiology and Allied Sciences

Dr. Divya Singh, received her PhD in Immunology from Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow in 2006. Currently she is working as Scientist ‘E’,
in Immunomodulation Division at DRDO Defence Institute of Physiology and Allied Sciences, Delhi.

Lilly Ganju, DRDO Defence Institute of Physiology and Allied Sciences

Dr Lilly Ganju, received her PhD from Barkatullah University, Bhopal. Currently working as Scientist ‘G’, in Immunomodulation Division at DRDO-Defence Institute of Physiology and Allied Sciences, Delhi. She has more than 80 research publications to her credit.

Bhuvnesh Kumar, DRDO Defence Institute of Physiology and Allied Sciences

Dr Bhuvnesh Kumar, Sc ‘H’ / Director of DRDO-Defence Institute of Physiology and Allied Sciences, Delhi, Delhi obtained his PhD (Veterinary Medicine) from G.B. Pant University of Agriculture and Technology, Pantnagar (Uttarakhand). Earlier he was Project Director of Low Intensity Conflicts to Counter Terrorism and Insurgency, and the Director, Project Monitoring at Directorate of General Life Sciences, DRDO HQrs, and Director, DIHAR, Leh.

Shashi Bala Singh, National Institute of Pharmaceutical Education and Research (NIPER) Hyderabad.

Dr. Shashi Bala Singh is presently Director, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad. Formerly, she was the Director General (Life Sciences), DRDO and Director of two DRDO Labs, DIHAR, Leh and DIPAS, Delhi. She obtained her Ph.D. degree in Human Physiology from All India Institute of Medical Sciences, New Delhi and D.Sc. degree in Physiology form Bharathiar University, Coimbatore. She is the elected fellow of National Academy of Sciences, India; National Academy of Medical Sciences and Indian Academy of Neurosciences.