A Hypothetical Tool for Integrated Omics, Drugs and Clinical Stem Cell Data Analysis

  • Yogesh Kumar Verma Division of Stem Cell & Gene Therapy Research, Institute of Nuclear Medicine & Allied Sciences, Delhi
  • Gurudutta Gangenahalli Division of Stem Cell & Gene Therapy Research, Institute of Nuclear Medicine & Allied Sciences, Delhi
Keywords: Integrated system analysis, Omics-drugs-disease-clinical databases, Tissue engineering, Radiation injury

Abstract

Understanding the molecular basis of stem cell (SC) function is essential to regenerate damaged tissue due to various types of injuries and pathologies. However, there are bottlenecks that prevent the use of Stem cell in the treatment of wide range of diseases. Complete information regarding the control of gene expression in Stem cell is necessary to understand the regulation of Stem cell fates such as self-renewal, differentiation, migration/ homing and apoptosis. However, in the absence of multi-functional, single window tool for the analysis of various omics and drugs data related to Stem cell, the knowledge consolidation is missing to fully harness its potential. A tool which can integrate various databases, analysis software and gives a probable solution for Stem cell mediated regeneration of tissues using available therapeutic options would likely to help in reducing morbidity and mortality associated with various pathologies. This subsumes omics based repurposing of drugs for Stem cell guided tissue regeneration, which will be a boon for clinicians to treat various debilitating diseases/ malfunctions.

Author Biographies

Yogesh Kumar Verma, Division of Stem Cell & Gene Therapy Research, Institute of Nuclear Medicine & Allied Sciences, Delhi

Dr Yogesh Kumar Verma, completed his MSc and PhD in Biomedical Science from Delhi University. Presently working as Scientist ‘D’ in Institute of Nuclear Medicine and Allied Sciences, Delhi. He has 21 publications and 03 patents (filed) to his credit. He is presently working in the area of stem cell research, microencapsulation, tissue engineering and omics data mining and analysis for decreasing various types of injuries.

Gurudutta Gangenahalli, Division of Stem Cell & Gene Therapy Research, Institute of Nuclear Medicine & Allied Sciences, Delhi

Dr Gurudutta Gangenahalli, presently an Additional Director and Head of the Division of Stem Cell Research at Institute of Nuclear Medicine and Allied Sciences, Delhi. He worked in the area of therapeutic potential human stem cell fate response signaling, such as apoptosis, adherence, osteogenesis, differentiation, homing, by using genetic-engineering of human stem cell genes (of CD34, BCL-2, CXCR4, PU.1, SCFr/c-Kit, APC, OSx, Wnt etc) and by high-throughput gene-expression analysis. He is also involved in developing the human stem cell shielding formulations and NMR stem cell tracking methods.

Published
2017-08-03
How to Cite
Verma, Y., & Gangenahalli, G. (2017). A Hypothetical Tool for Integrated Omics, Drugs and Clinical Stem Cell Data Analysis. Defence Life Science Journal, 2(3), 354-357. https://doi.org/10.14429/dlsj.2.11673