In-vitro Evaluation of Bis-pyridinium Oximes Connected by Xylene Linkers as Reactivators of DFP-inhibited Electric EEL Acetylcholinesterase
Keywords: Bis-pyridinium oximes, Reactivators, 2-PAM, DFP, organophosphorus pesticides, nerve agents, acetylcholinesterase, obidoxime
AbstractBis-pyridinium oximes connected by xylene linkers were synthesised and their in-vitro reactivation efficacy was evaluated for DFP inhibited AChE. The reactivation efficacy data were compared with those of 2-PAM and obidoxime. However, it was observed that none of these oximes were able to surpass the reactivation efficacy of 2-PAM and obidoxime in reactivating DFP inhibited AChE. 2-PAM and obidoxime respectively exhibited
52 per cent and 43 per cent reactivation of DFP inhibited AChE, where as the synthesised oximes 3a, 3d, and 3f showed 37 per cent, 30 per cent, and 31 per cent reactivation, respectively within 10 min at 10-3 M.
How to Cite
Acharya, J., Karade, H., Raviraju, G., Ghosh, S., & Gupta, A. (2016). In-vitro Evaluation of Bis-pyridinium Oximes Connected by Xylene Linkers as Reactivators of DFP-inhibited Electric EEL Acetylcholinesterase. Defence Life Science Journal, 1(2), 162-166. https://doi.org/10.14429/dlsj.1.10736
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