TY - JOUR AU - Kumud Joshi AU - Danswrang Goyary AU - Bhaskar Mazumder AU - Sumit Kishor AU - Piyali Dey AU - Yangchen Bhutia AU - Sanjeev Karmakar AU - Pronobesh Chattopadhyay AU - Sanjai Dwivedi PY - 2020/04/08 Y2 - 2024/03/28 TI - Development and Standardisation of a Method for Inflicting Frostbite Injury in Rats and Formulation of Essential Oil in Treatment of Frostbite JF - Defence Life Science Journal JA - DLSJ VL - 5 IS - 2 SE - Special Issue Paper DO - 10.14429/dlsj.5.15606 UR - https://publications.drdo.gov.in/ojs/index.php/dlsj/article/view/15606 AB - Frostbite is a cold induced injury which occurs due to exposure of a particular site of body to sub-zero temperature. One of the primary reasons for lack of proper studies about the underlying mechanism of frostbite injury is due to non-availability of any reliable animal model and method for inflicting frostbite. In our current research, a device was designed and standardised to inflict frostbite wound in wistar rat. A formulation comprising different combination of essential oils was also developed and its activity was assessed and found effective in the treatment of frostbite wound. ER -