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 | Fluorinated epoxy resins based sorbent coating materials for quartz pezoelectric crystal detector
Author : Gupta, D. C.;Gutch, P. K.;Lal , G.;Vyas, K. D.;Jaiswal, D. K.
Source : Defence Science Journal ; Vol:54(2) ; 2004 ; pp 229-234
Subject : 620.1 Material Science and Technology
Keywords : Fluoroepoxy resins;Sorbent coating material;Detection;Organophosphorus compounds;Piezoelectric detector;Fluoroepoxypolymers;Coating materials;Crystal detector
Abstract : Fluorinated epoxy resins were synthesized and evaluated as sorbent coating materials for the detection of organophosphorus compounds using quartz piezoelectric crystal detector. These resins were prepared by reacting excess of epichlorohydrin with each of or in combination of fluorinated diols, ie, (alpha),(alpha),(alpha)',(alpha)', tetrakis (trifluoromethyl) 1,3 benzene dimethanol (TTFMBD), 4,4’ bis-2-hydroxy hexafluoro isopropyl) biphenyl(BHHFIBP),4,4 dihydroxyocata fluorodiphenyl(DHOFDP) and 2,2,3,3,4,4 hexafluoro 1,5 pentanediol(HFPD) in the presence of sodium hydroxide at reflux temperature. These polymers were extracted in organic solvents and dried. Each of these fluoroepoxy resins were coated over quartz piezoelectric crystal by solution-casting method and tested using dimethylmethyl phosphonate (DMMP) as model compound. Change in the frequency(Delta F) of quartz piezoelectric crystal oscillator was recorded. Sensitive and potential fluorinated epoxy resins, ie, diglycidylethers (DGE) of HFPD-TTFMBD (in the molar ratio 6:4) and DGE (HFPD-BHHFIBP in the molar ratio) were characterized by viscostity, number average molecular weight (Mn), epoxy equivalent, infrared spectroscopy, and thermal stability. |
| | Amifostine : An effective prophylactic agent against sulphur mustard toxicity
Author : Pathak, Uma ;Raza, S. K.;Vijayraghavan, R. ;Jaiswal, D. K. ;Kumar, P.
Source : Defence Science Journal ; Vol:52(4) ; 2002 ; pp 439-444
Subject : 57.089 Biomedical Sciences ;57 Biological Sciences
Keywords : Amifostine ;Sulphur mustard ;Prophylactic agent ;Radioprotector ;Toxicity ;Alkylating agent
Abstract : Amifostine, S-2-(aminopropylamino) ethylphosphorothioate and two of its analogues have been evaluated as prophylactic agent against SM toxicity. The compounds were administered intraperitoncally (i.p.) at 0.2 LD/sub59 dose in mice 30 min prior to dermal application of SM. The protective efficacy was determined by observing the mortality for 14 days. The protection offered by amifostine was better than its analogues. Subsequent study on time-dependent protection, carried out with amifostine (0.2 LD/sub50, i.p.) provided significant protection when the drug was administered as 30 min pre-treatment and simultaneous treatment against SM at 155 mg.kg/-1 dose (equal to 19-fold LD/sub50). Furthermore, oral administration of amifostine (30 min pre-treatment) showed similar results. These findings suggest that amifostine is a promising prophylactic agent against SM toxicity. |
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