| || Preparation of Oxime HI-6 (Dichloride and Dimethanesulphonate) Antidote against Nerve Agents
Author : Kuca, Kamil;Stodulka, Petr;Hrabinova, Martina
Source : Defence Science Journal ; Vol:58(3) ; 2008 ; pp 399-404
Subject : 57.089 Biomedical Sciences ;57 Biological Sciences
Keywords : HI-6;Acetylcholinesterase;Nerve agent;Quaternary salts;Oxime;Reactivator;Antidote;Organophosphate
Abstract : Because of the threat of misuse of nerve agents as terroristic weapons by the terrorists, an immediate need is felt for the preparation of antidotes on large-scale basis. HI-6 (dichloride and dimethanesulphonate) salt are the most promising acetylcholinesterase reactivators used as causal antidotes in nerve agents intoxication. In this study, rapid and large-scale preparation of oxime HI-6, the most promising reactivator has been described.