 | Sulphonamide bases |
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 | Studies in Heterocyclic Compounds Part XXXIII : Synthesis and in vitro screening of some 1 3 diaryl 5 arylazo N substituted p sulphmulbenzeneazo dihydro 2 thioxo 4 6 1H 5H pyrimidinedioes
Author : Sharma, H.R. ;Saharia, G.S.;Nigam, S.C.
Source : Defence Science Journal ; Vol:31(1) ; 1981 ; pp 15-22
Subject : 54 Chemistry;547 Organic Chemistry
Keywords : Diazotised sample ;Sulphonamide bases
Abstract : 1-Phenyl-3-(p-methoxyphenyl)- and 1,3-di(p-methoxyphenyl) dihydro-2-thioxo-4,6 (1H, 5H)-pyrimidinediones have been synthesised and coupled with different diazotised simple and sulphonamide bases to furnish the corresponding 5-(arylazo/N- substituted p-sulphamylbenezeneazo)dihydro-2-thioxo-4, 6(1H, 5H)-pyrimidinediones. On in vitro screening these were found to exhibit considerable activity against a number of micro-organisms. |
| | Studies in Sulphonamides Part XIII: Synthesis of Some new 1 methyl 3 ary 1 2 arylazo N substituted P sulphamylbenzeneazo propane 1 3 diones as potential antibacterials
Author : Sharma, H.R. ;Saharia, G.S.;Nigam, S.C.
Source : Defence Science Journal ; Vol:32(2) ; 1982 ; pp 87-94
Subject : 54 Chemistry;547 Organic Chemistry
Keywords : Sulphonamide bases
Abstract : Two 1-methyl-3-arylpropane-1,3-diones viz., 1-methyl-3(2',4'-dimethoxyphenyl)-and l-methlyl-3(3',4'-dimethoxyphenyl) propane-1,3-diones have been synthesised and coupled with diazotised simple and sulphonamide bases in presence of sodium acetate to furnish the corresponding 1-methyl-3(2',4'-3',4'-dimethoxyphenyl)-2 (arylazo/N-substituted p-sulphamylbenzeneazo)propane-1,3-diones. All these compounds were later subjected to in vitro screening against S. aureus, E. coli and p.pyocyanea when these showed considerable activity. |
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