| || Comparative Study of Acetazolamide and Spironolactone on Regional Blood Distribution on Exposure to Acute Hypobaric Hypoxia
Author : Parshad, R. ;Divekar, H.M.;Singh, M.V.;Jain, S.C.
Source : Defence Science Journal ; Vol:35(4) ; 1985 ; pp 425-429
Subject : 61 Medical Sciences
Keywords : Oral treatment ;Radio iodinated serum albumin
Abstract : Regional blood distribution was studied in rats, which were divided into four groups viz., (i) control, (ii) exposed to acute hypobaric hypoxia, (iii) exposed to acute hypobaric hypoxia after oral treatment with 25 mg acetazolamide, and (iv) exposed to acute hypobaric hypoxia after oral treatment with 6 mg spironolactone. The regional blood distribution was measured using radio-iodinated serum albumin (R/sup 131/ISA). The acute hypoxic exposure results in major readjustment in the blood flow to the various organs mainly from the renal and splanchic vascular beds to the heart and brain. Treatment with acetazolamide and spironolactone results only in a slight decrease in blood contents of the heart, brain and lungs as compared to the hypoxia alone exposed group.
| || Haematological Studies in High Altitude Natives at Plains and on Return to High Altitude
Author : Jain, S.C.;Divekar, H.M. ;Bardhan, Jaya;Sharma, R.S.;Swamy, Y.V.
Source : Defence Science Journal ; Vol:38(2) ; 1988 ; pp 197-201
Subject : 612 Physiology;61 Medical Sciences
Keywords : Physiology;Biochemistry
Abstract : Haematologic studies were carried out in 20 high altitude natives during two months stay at plains (200 m) and on their return to an altitude of 3,500 m. Haemoglobin, erthrocyte count, haematocrit and reticulocyte count decreased rapidly on arrival to plains and attained minimum level by the end of fourth week. All these parameters increased rapidly on return to high altitude and were found to attain maximum values by 23rd day on return to high altitude. Mean cell volume and mean cell haemoglobin showed significant increase at altitude. It is concluded that the high altitude natives of Ladakh were well adapted to hypoxic environment due to normocythaemic hypervolemia.