| || Comparative Evaluation of Carbamates as Prophylactic Agents against Organophosphate Intoxication Rats
Author : Chatterjee, A.K.
Source : Defence Science Journal ; Vol:42(2) ; 1992 ; pp 85-87
Subject : 615.9 Toxicology;61 Medical Sciences
Keywords : Carbamates ;Physostigmine;Pyridostigmine;Nerve gas toxicity;DFP poisoning
Abstract : Investigates the effects of two well-known carbamates, physostigmine and pyridostigmine against organophosphorous compound and nerve gas toxicity. Physostigmine pretreatment for 30 min enhanced the survival time of rats against DFP intoxication whereas it did not have any effect with sarin poisoning. However, pyridostigmine pretreatment did not produce any significant effect on survival time either against DFP or sarin intoxication. Treatment with atropine along with carbamates further enhanced significantly the survival time against DFP poisoning.