| || Synthesis of p (Di n propylsulphamyl) Benzoic Acid
Author : Shukla, K.K.;Chaudhry, Govind Rai
Source : Defence Science Journal ; Vol:18(4) ; 1968 ; pp 239-240
Subject : 532.542 Fluid Dynamics
Keywords : Penicillin;Benemid Probenecid;Chronic Gouty Arthritis
Abstract : A process for the synthesis of p-carboxybenzene sulphonylchloride by oxidation of toluene-p-sulphonylchloride as well as toluene-p-sulphonic acid has been developed. p-carboxybenzene sulphonylchloride on condensation with di-n-propylamine yield p-(di-n-propylsulphamyl)-benzoic acid, an uricusuric agent employed in chronic gouty arthritis and used as an antiuric adjuvant known in trade as "Benemid, Probenecid".