| || Changes in plasma leptin and zinc status of women mountaineers at high altitude
Author : Suri, Shobha ;Salhan, Ashok ;Singh, Som Nath ;Selvamurthy, W.
Source : Defence Science Journal ; Vol:52(2) ; 2002 ; pp 173-179
Subject : 61 Medical Sciences
Keywords : Leptin ;Medical science ;Alkaline phosphatase
Abstract : "The loss of body weight due to suppressed appetite at high altitude is very common. The hormone leptin and trace metal zinc have key roles in appetite regulation. In the present study, changes in leptin and zinc status of female mountaineers with and without supplementation with zinc have been investigated. Plasma leptin, zinc and enzyme activities of alkaline phosphatase (EC 184.108.40.206) and 5' nucleotidase (EC 220.127.116.11) of 25 women mountaineers between age group 17-25 yr were studied. The women mountaineers were divided into two groups, i.e., placebo control (n = 7) and supplemented with zinc at dose 15 mg/day for 21 days (n = 18) and all variables were analysed initially at 1981 m, at high altitude (4572-5182 m) and on return to initial altitude. The basal leptin level for both the groups combined was 3.12 ± 0.57 ng/ml (mean ± SD). Plasma leptin levels were found increased by 24 per cent and 58 per cent, respectively at high altitude and after return in case of control group, whereas in case of zinc-supplemented group, there was a statistically non-significant decrease of 20 per cent at high altitude in comparison to basal values. Thereafter, levels were maintained at baseline. There was no significant change in zinc status of control group as indicated by plasma zinc as well as maintained activities of alkaline phosphatase and 5' nucleotidase in the present study. On the other hand, zinc-supplemented group showed increase in zinc status at high altitude, which was evident by increased plasma zinc levels. On return from high altitude, plasma zinc levels were low in comparison to high altitude but still higher than that of basal. Results indicate beneficial effects of zinc supplementation by decreasing leptin levels at high altitude. "
| || Toxicology of Biomedical Polymers
Author : Fernandez, A.C. ;Vedanarayanan, P.V.
Source : Defence Science Journal ; Vol:37(2) ; 1987 ; pp 173-183
Subject : 615 Pharmacology;615.9 Toxicology
Keywords : Polymer science ;Medical science
Abstract : This paper deals with the various types of polymers, used in the fabrication of medical devices, their diversity of applications and toxic hazards which may arise out of their application. The potential toxicity of monomers and the various additives used in the manufacture of biomedical polymers have been discussed along with hazards which may arise out of processing of devices such as sterilization. The importance of quality control and stringent toxicity evaluation methods have been emphasised since in our country, at present, there are no regulations covering the manufacturing and marketing of medical devices. Finally the question of the general and subtle long term systemic toxicity of biomedical polymers have been brought to attention with the suggestion that this question needs to be resolved permanently by appropriate studies.
| || Drugs Behaviour and the Brain Chemistry
Author : Wagner, Henry N.
Source : Defence Science Journal ; Vol:41(2) ; 1991 ; pp 137-141
Subject : 61 Medical Sciences;616.8 Neurology
Keywords : Medical Science ;Neurology
Abstract : Abstract not available.
| || Biotechnology in India : Current scene
Author : Nagaratnam, A.
Source : Defence Science Journal ; Vol:51(4) ; 2001 ; pp 401-408
Subject : 60 Biotechnology
Keywords : Biotechnology;Medical science;Transgenics;Tissue culture;Seriobiotechnology;Animal biotechnology;Bio prospecting;Marine biotechnology;Immunomodulators
Abstract : "Realising the immense potential of biotechnology in the fields of agricultural production and health care, especially in developing countries, India has been devoting special attention over the past two decades to biotechnology and its applications. Necessary infrastructure has been built-up, the human resources and technical expertise built-up, and fruitful interactions between academic institutions and industries supported. The Department of Biotechnology, Govt of India has been playing a major role in this endeavour. Special efforts are being made to ensure practical applications of laboratory research. Salient achievements in the areas of agriculture (including tissue culture, transgenics, sericulture, animal, marine and microbial biotechnology, biofertilisers, bio-control agents, bio-prospecting, conservation of biodiversity and environment) and health care (including genetic counselling, DNA fingerprinting, preservation and propagation of human cell lines, medicinal biotechnology with special reference to indigenous medicinal plants, and immunodiagnostics for human beings and animals) are reviewed. "
| || Some Mathematical Aspects of Spread and Stability of Time-Delay Gonorrhea
Author : Srinivas, N.C. ;Ramacharyulu, N. Ch. Pattabhi
Source : Defence Science Journal ; Vol:41(3) ; 1991 ; pp 277-293
Subject : 51 Mathematics
Keywords : Epidemic diseases ;Mathematical models;Medical science
Abstract : A mathematical model of time-delay gonorrhea among hetero and homosexuals is presented as a system of first order ordinary coupled integro-differential equations with delayed arguments. A theorem on the positivity of the solutions is proved to establish the feasibility of the proposed mode. Further, the only possible diseased equilibrium state has been identified and the stability analysis of such a state for some epidemiological possibilities has been carried out. It has been observed that the impulsive type inflow of infectives into the population maintained the stability of the diseased equilibrium state and is valid even for the exponential type inflows. In contrast to this, instability sets in when one or other of infective inflows is of the gate type.
| || Prevalence of Dengue Infection in India
Author : Pandya, G.
Source : Defence Science Journal ; Vol:32(4) ; 1982 ; pp 359-370
Subject : 61 Medical Sciences
Keywords : Pathology ;Medical science
Abstract : Infections attributable to dengue viruses have been frequently occurring in India, as also in South East Asian countries. Benign clinical manifestations, have been rampant in this country. Various aspects of dengue infections in the context of India e.g., occurrence, clinical profile, viral isolations, serological surveys, pathogenicity and vector ecology have been discussed in the present review.