| || Radioimmunotargeting : Some Recent Advances
Author : Hazra, D.K.
Source : Defence Science Journal ; Vol:40(4) ; 1990 ; pp 373-381
Subject : 61 Medical Sciences
Keywords : Single domain antibody;Oncogene coded protein;Intracellular target;Radionuclides;Neoplastic lesions;Radioimmunoscintigraphy;Pancarcinoma
Abstract : Several new aspects of radioimmunotargeting for neoplastic lesions are reviewed in this paper. These include the use of single domain antibody, oncogene-coded protein and other intracellular targets so as to obtain pancarcinoma reactivity, newer methods of linking /sup 99m/Tc to antibodies for radioimmunoscintigraphy. The selection of candidate radionuclides for radioimmunotherapy, particularly the possible use of radiosilver and radiogold, and the strategies of enhanced tumour targeting were also reviewed.