| || Chemical radioprotectors
Author : Upadhyay, S. N.;Dwarakanath, B. S.;Ravindranath, T.;Mathew, T.L.
Source : Defence Science Journal ; Vol:55(4) ; 2005 ; pp 403-425
Subject : 61 Medical Sciences;57.089 Biomedical Sciences
Keywords : Radioprotectors;Radiation damage;Chemical radioprotectors;Herbal radioprotectors;Radiation injury;WR-2721;Bisbenzimidazole;Hoechst-33258;Analogue Hoechst-33342
Abstract : Protection of biological systems against radiation damage is of paramount importance during accidental and unavoidable exposure to radiation. Several physico-chemical and biological factors collectively contribute to the damage caused by radiation and are, therefore, targets for developing radioprotectors. Work on the development of chemicals capable of protecting biological systems from radiation damage was initiated nearly six decades ago with cysteine being the first molecule to be reported. Chemicals capable of scavenging free radicals, inducing oxygen depletion, antioxidants and modulators of immune response have been some of the radioprotectors extensively investigated with limited success. Mechanism of action of some chemical radioprotectors and their combinations have been elucidated, while further understanding is required in many instances. The present review elaborates on structure-activity relationship of some of the chemical radioprotectors, their evaluation, and assessment, limitation, and future prospects.