| || Immunotoxicology: Modulation of the Immune System by Xenobiotics
Author : Nagarkatti, Mitzi ;Nagarkatti, Prakash S.
Source : Defence Science Journal ; Vol:37(2) ; 1987 ; pp 235-244
Subject : 61 Medical Sciences
Keywords : Immunotoxicological screening ;Immune system;Immunity
Abstract : Starting with a definition of immunity, this review describes general mechanisms by which immune system is modulated and details several immunotoxicological screening methods to assess the immumologic and host resistance alterations following chemical exposure. Among a variety of immuno toxic compounds known, only four representative compounds namely o-chloro benzylidine malonoitrile (CS), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), chloroquine 1,3-bis (2-chloroethyl) 1-nitrosourea (BCNU) have been chosen for an elaborate discussion.